Hb Aalesund (HBA2: c.400_406delAGCACCG), an Unstable α-Globin Variant Found in a Norwegian Patient Causing Moderate Hemolytic Anemia and Falsely High Hb A1c Using Ion Exchange High Performance Liquid Chromatography
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چکیده
منابع مشابه
Standardization of method for determining glycosylated hemoglobin (Hb A1c) by cation exchange high performance liquid chromatography
Hemoblobin A1c is the most important parameter for the monitoring of metabolic control of patients with diabetes mellitus. The purpose of this study was to adapt the Mono S method to a conventional HPLC system, allowing highly selective HbA1c determination without the acquisition of kits or the use of dedicated systems The results obtained were compared to the Tinaquant® immune turbidimetric me...
متن کاملMeasurment of stable Glycosylated Hemoglobin (Hb A1) and Its unstable type (pre- Hb A1c) with the lon- exchange Chromatography in Diabetic patients
SUMMARY: At present, measurment of glycosylated hemoglobin, especially the stable fraction of hemoglobin (HbA1c) is one of the ways to control diabetes because this measurment can demonstrate total glycemia during last 1.2.3 months. Glycosylated hemoglobin is seen in 3 forms: Ala Alb A1c. Among these hemoglobin Alc is quantitively more than other 2 forms and its difference with other hemoglobi...
متن کاملSevere hemolytic anemia associated with the homozygous state for an unstable hemoglobin variant (Hb Bushwick).
We have investigated a 13-year-old girl from first cousin parents who presented with severe hemolytic anemia. Hematologic studies showed unstable hemoglobin (Hb) disease (chronic Heinz body anemia), and DNA analysis showed that the patient was homozygous for the previously reported abnormal Hb called Hb Bushwick (beta 74E18 gly-->val). Hb Bushwick is unstable in vitro and in vivo. In addition, ...
متن کاملComparing electrophoresis at alkaline pH and high performance liquid chromatography to diagnose Hb S-like hemoglobin
1. Callera F, Vital Brasil AA, Casali AR, Mulin CC, Rosa ES, Barbosa MA, et al. Oncohematological diseases in the Vale do Paraíba, State of São Paulo: demographic aspects, prevalences and incidences. Rev Bras Hematol Hemoter. 2011;33(2):120-5. 2. Head DR, Cerezo L, Savage RA, Craven CM, Bickers JN, Hartsock R, et al. Institutional performance in application of the FAB classification of acute le...
متن کاملA novel deletion of β-globin promoter causing high HbA2 in an Indian population.
β-thalassemia is the most common inherited disorder characterized by a reduction or absence of β-globin chain synthesis. So far, over 200 mutations have been identified that result in β-thalassemia. Most of the mutations are single nucleotide substitutions or deletions, or insertions in the β-globin gene or its flanking sequences. Heterozygous β-thalassemia usually presents with mild microcytic...
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ژورنال
عنوان ژورنال: Hemoglobin
سال: 2019
ISSN: 0363-0269,1532-432X
DOI: 10.1080/03630269.2019.1614048